Constructed in 1865, the building was originally an all-girls’ Anglican college named Collegiate School for Young Ladies. The name soon changed to Angela College in recognition of its generous benefactor, Lady Angela Burdett-Coutts of England. After the school closed in 1905, it was reinvented in 1908 as the residential Angela Hotel.

The hotel was managed by numerous owners over the following years but was eventually sold in 1959 to the Sisters of St. Ann, who converted the Angela Hotel into a retirement home for their order, created space for a chapel and renamed the building Mount Saint Angela. In 1992 it was designated heritage and the sisters won a Hallmark Society Award for their restoration of the building the following year.

In 2006 the Isherwood family – who had sold the building to the sisters in 1959 – bought back Mount Saint Angela and the building is now leased to Island Health and acts as a facility for those with disabilities.