Onondaga is the capital of the Iroquois League, serving as the meeting place of the Iroquois Grand Council since the mid-1400s. The League, originally made up of the Five Nations, was an early democratic government with a system that may have had an influence on the government of the United States.

Genesis Cities have a set location on a model of Earth in the game CryptoCrusades. The Genesis Cities, 88 in total, will be the seats of 88 empires on iOS and Android when the game is launched.