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创作者 Glycomics
创作者 Glycomics
O-linked glycans are a common covalent modification of serine and threonine residues of mammalian glycoproteins. The most common type of O-linked glycans found on secreted mammalian glycoproteins and mucins (proteins conjugated to carbohydrate) is from the addition of N-acytylgalactosamine (GalNac) to serine or threonine residues. The Core 1 structure is generated by the addition of galactose b1-3 to this GalNAc. The Core 2 structure is generated by the further addition of N-acetyl-glucosamine b1-6 to the N-acetyl-galactosamine on the Core 1 structure. In total eight different O-linked glycans core structures have been identified and all of these can be further elongated by the addition of a number of monosaccharides including sialic acids.
This 3D model was generated using SGI (Silicon Graphics) Octane IRIX workstation in 2002.
Glycans are information-rich molecules based on complex carbohydrates (sugars or polysaccharides), attached to proteins, lipids and cells.
All 3D models in this collection were generated using SGI (Silicon Graphics) Octane IRIX workstation in 2002.
Glycans are key players for recognition processes within cells, and between them. Understanding the interaction between glycans and bacteria or viruses outside the cell is critical for our body functions, disease presentation, diagnosis and therapeutics development and vaccine.
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Glycomics #72_O-linked glycosylation (core 4)
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Glycomics
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创作者 Glycomics
创作者 Glycomics
O-linked glycans are a common covalent modification of serine and threonine residues of mammalian glycoproteins. The most common type of O-linked glycans found on secreted mammalian glycoproteins and mucins (proteins conjugated to carbohydrate) is from the addition of N-acytylgalactosamine (GalNac) to serine or threonine residues. The Core 1 structure is generated by the addition of galactose b1-3 to this GalNAc. The Core 2 structure is generated by the further addition of N-acetyl-glucosamine b1-6 to the N-acetyl-galactosamine on the Core 1 structure. In total eight different O-linked glycans core structures have been identified and all of these can be further elongated by the addition of a number of monosaccharides including sialic acids.
This 3D model was generated using SGI (Silicon Graphics) Octane IRIX workstation in 2002.
Glycans are information-rich molecules based on complex carbohydrates (sugars or polysaccharides), attached to proteins, lipids and cells.
All 3D models in this collection were generated using SGI (Silicon Graphics) Octane IRIX workstation in 2002.
Glycans are key players for recognition processes within cells, and between them. Understanding the interaction between glycans and bacteria or viruses outside the cell is critical for our body functions, disease presentation, diagnosis and therapeutics development and vaccine.
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